Volume 2, Issue 1, March 2018, Page: 1-5
Effects of Experemental Cerebral Ishemia on Metabolic Characteristics of Parietal Cortex Neurons
Lizaveta Igorevna Bon, Department of Pathological Physiology of the Name of D. A. Maslakov, Grodno State Medical University, Grodno, Belarus
Nataliya Yevgenyevna Maksimovich, Department of Pathological Physiology of the Name of D. A. Maslakov, Grodno State Medical University, Grodno, Belarus
Sergey Michailovich Zimatkin, Department of Histology, Cytology and Embryology, Grodno State Medical University, Grodno, Belarus
Received: Feb. 21, 2018;       Accepted: Mar. 9, 2018;       Published: Apr. 3, 2018
DOI: 10.11648/j.be.20180201.11      View  1150      Downloads  39
The aim of the paper was to estimate the effect of experimental cerebral ischemia on metabolic characteristics of parietal cortex neurons. The experiments were carried out on 12 laboratory male rats. Cerebral ischemia was modeled with bilateral joint carotid arteries with durations of 60 minutes under intravenous thiopental anesthesia (40-50 mg / kg). The rats were decapitated and the samples of the brain parietal cortex were prepared for histological and histochemical examination in combination with morphometry to examine the 5th layer inner pyramidal neurons. It was increased the number of pathological forms and shrinkage of the 5th layer inner pyramidal neurons after cerebral ischemia in rats. The histochemical examination was revealed the inhibition of NADH-, glucose-6-phosphate dehydrogenase and succinate dehydrogenases as well as activation of lactate dehydrogenase and acid phosphatase. Cerebral ischemia induces deep histological and histochemical changes in the parietal cortex neurons in rats, including shrinkage of parietal cortex neurons and disturbances of their energy metabolism.
Cerebral Ischemia, Parietal Cortex, Neurons
To cite this article
Lizaveta Igorevna Bon, Nataliya Yevgenyevna Maksimovich, Sergey Michailovich Zimatkin, Effects of Experemental Cerebral Ishemia on Metabolic Characteristics of Parietal Cortex Neurons, Bioprocess Engineering. Vol. 2, No. 1, 2018, pp. 1-5. doi: 10.11648/j.be.20180201.11
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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